RESULTS: For NSAIDs overall, ever use (>2 prescriptions) compared with nonuse (≤2 prescriptions) was associated with a decreased risk of SCC (IRR, ; 95% confidence interval [CI], -) and MM (IRR, ; 95% CI, -), especially for long-term use (≥7 years) and high-intensity use (>25% prescription coverage during the total duration of use). NSAID use was not associated with a reduced risk of BCC overall (IRR, ; 95% CI, -), but the risk of BCC at sites other than the head and neck was reduced in association with long-term use (IRR, ; 95% CI, -) and high-intensity use (IRR, ; 95% CI, -). All estimates of reduced risk were driven primarily by the use of nonselective NSAIDs and older COX-2 inhibitors (diclofenac, etodolac, and meloxicam).
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